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KMID : 0861020170320020041
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Korea Journal of Herbology
2017 Volume.32 No. 2 p.41 ~ p.47
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Effects of Yeonsan Ogye on monosodium iodoacetate-induced osteoarthritis in rats
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Sim Boo-Yong
Choi Hak-Joo
Ji Joong-Gu
Kim Dong-Hee
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Abstract
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Objective : The aim of this study is to investigate anti-arthritis activity using a korea`s natural monument No. 265 designate `Yeonsan-Ogye`. In this study, research by using extracts from different concentration of the Yeonsan- Ogye through an MIA-induced arthritis animal model was being conducted in vivo and scientifically verifying the efficacy of medicinal food.
Methods : Yeonsan-Ogye was administered 500 ㎎/㎏/day, 1000 ㎎/㎏/day, 2000 ㎎/㎏/day to SD-Rat, where arthritis was induced by monosodium iodoacetate (MIA) at 60 ㎎/㎖. MMP-9, COMP, CTXⅡ, calcitonin and glycosaminoglycan level in serum were measured by ELISA. The changes of relative hind paw weight bearing ratio by Incapacitance Test Meter and The cartilage of meniscus volume was examined and 3-D high-resolution reconstructions of the cartilage of meniscus were obtained using a Micro-CT system. Also, the histopathological analysis of knee was observed by H&E and safranin-O staining.
Results : Production of MMP-9, COMP (all groups) and CTXⅡ (500, 1000 ㎎/㎏/day) level in serum was decreased, respectively, in comparison with control. The other way, production of calcitonin (500, 1000 ㎎/㎏/day) and glycosaminoglycan (all groups) level in serum, Hind paw weight bearing ratio (all groups) was increased, espectively, in comparison with control. The cartilage of patella volume in micro-CT increased significantly. In addition, all groups showed a increase in the cartilage volume and proteoglycan.
Conclusion : The results for Yeonsan-Ogye showed significant antiarthritis activity in serum and the cartilage. Therefore, it is thought to be that Yeonsan Ogye can be utilized as a variety of new korea medicie and health foods against arthritis diseases.
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KEYWORD
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antiarthritis, medicine food, MIA, osteoarthritis, Yeonsan-Ogye
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